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LBA-2: A New Cause of Hereditary and Acquired Erythrocytosis

At ASH 2024, François Girdon and Betty Gardie presented a Late Breaking Abstract on a new cause of erythrocytosis. The study aimed to investigate unexplained cases of hereditary and acquired erythrocytosis with normal erythropoietin (EPO) levels. The team identified a hepatic-like variant of EPO with enhanced activity, resembling fetal liver-derived EPO, as the driver of red blood cell overproduction. These findings suggest a need for qualitative EPO analysis in clinical practice to improve the diagnosis of idiopathic erythrocytosis.

Betty Gardie & François Girdon

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